The remaining two men's singles semifinal spots are up for grabs on Wednesday and fans should prepare for fireworks.
In the first of the two clashes, a pair of unexpected first-time AO quarterfinalists face off.
Headlining the night session, a much-anticipated battle awaits between a certain Serbian nine-time AO champion and a player appearing in his second quarterfinal at Melbourne Park in three years.
Andrey Rublev [5] v Novak Djokovic [4]
Head-to-head: 1-2
The Serbian star has famously compared his comfort levels on Rod Laver Arena to that of his living room.
Djokovic's staggering success on the most famous court in Australia is somewhat mind-blowing: he has never lost a semifinal or a final at the year's first major.
Still, he's not invincible on his favourite court. He has lost three times at the quarterfinal stage: in 2014, to eventual champion Stan Wawrinka; in 2010, to Jo-Wilfried Tsonga; and 2009, when he retired citing heat illness against Andy Roddick.
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That statistic alone won’t give 25-year-old Rublev much confidence as they square off for a fourth time.
He knows he needs to stand and deliver to earn a maiden major semifinal spot on his seventh attempt.
"The only chance I have is if I play my best tennis, just fight for every ball," said the powerful baseliner. "I know that Novak is [a] very tough player to beat, especially [in] the slams… he's one of the best in history."
Interestingly, all three of the pair’s duels have come in the past 15 months.
Though Rublev lost to the 21-time Grand Slam champion in consecutive Nitto ATP Finals, he dealt a 6-2 6-7(4) 6-0 knockout blow in the final of last year's Serbia Open, Djokovic's home tournament.
READ: Red-hot Rublev keeps calm to carry on
"Incredible firepower, especially from the serve and forehand corner. Just a very explosive player," Djokovic said, describing Rublev.
But the Serb, as the only existing major champion among the AO 2023 men's final eight, knows he's a clear favourite not only against Rublev, but for the title.
The 35-year-old was untouchable on Monday, dropping only five games against Australian 22nd seed Alex de Minaur in a lopsided fourth-round meeting.
He made it clear in his on-court interview that a hamstring injury that impacted him during the first week is no longer an issue.
"[It was] definitely the best tennis I've played this year, this tournament, so far this season," said the Serb.
"The way I played, the way I felt, gives me reason now to believe that I can go all the way," Djokovic added.
Will his prophecy come true, at least in part? Tune in to find out.
Tommy Paul v Ben Shelton
Head-to-head: 0-0
At the tender age of 20 and on his first trip outside the United States, Ben Shelton surprised the tennis world and himself by making a Grand Slam quarterfinal in only his second major.
The left-hander, ranked No.89, said a complete lack of expectations has enabled him to hit freely, contributing to his unexpected success.
After saving match point against Zhang Zhizen in the opening round, Shelton again pulled through as an on-paper favourite against qualifier Nicolas Jarry and wildcard Alexei Popyrin.
He then surprised countryman J.J. Wolf in five sets in the pair's first meeting.
Another compatriot, Tommy Paul, who Shelton has practised with but never competed against, presents his toughest challenge yet.
READ: Shelton shaping up for shining career
"He's been one of the American guys who has kind of almost taken me under their wing, kind of helped me navigate some of the early stages of a professional career," said Shelton.
"He's been a good friend. I'm excited to get to play him on a big stage like this."
Putting friendship aside, the 25-year-old Paul has declared himself hungry to clinch a career-first Grand Slam semifinal berth.
"I'm not satisfied," said the world No.35 after dispatching 24th seed Roberto Bautista Agut on Monday. "I'm going to go out there and try and win the match - semifinal sounds a lot better than quarterfinal every day of the week."
Paul, who upset 30th seed Alejandro Davidovich Fokina in the second round, said camaraderie with long-time peers Taylor Fritz and Frances Tiafoe, who both had breakthrough 2022 seasons, has helped elevate his game.
"We're talking to each other, we help each other, we push each other, we want each other to do well," said Paul, describing a healthy rivalry between the trio.
"Obviously, I want to be the best one in the group. Fritz wants to be the best one in the group. Frances wants to be the best one in the group. Everyone wants to be the best. That's what makes it good, I mean, we're all competitive."
On Wednesday, Paul has a chance to match Tiafoe's US Open feat by reaching the final four at a major. Should Paul progress beyond that, he'll have the last laugh.