Wozniacki had won their only previous encounter, but the Belgian has also garnered a giant-slaying reputation, having beaten 2017 Wimbledon champion Garbine Muguruza in the second round on her return to the All England Club last year.
Van Uytvanck made her intentions clear in the opening game, going toe-to-toe with Wozniacki from the baseline before outfoxing her with a couple of drop shots to reach break point. The No.3 seed saw off the danger with some solid serving before turning the tables in the next game, bringing up a break point of her own that the world No.52 saved with an ace.
From the midpoint of the first set, however, Wozniacki seized control. A love hold was followed by a dogged defensive display to break serve, Van Uytvanck double-faulting on the fourth break point to slip 4-2 behind. That was enough to secure the first set that saw both players hit 14 winners, the Dane keeping her error count to just nine – half that of her opponent.