Australian wildcards Nick Kyrgios and Thanasi Kokkinakis and countrymen Matt Ebden and Max Purcell each upset seeds and will now face off in the first all-Australian men's doubles final since 1980.
MORE: Men's doubles results AO 22
Kyrgios and Kokkinakis earned the right to fight for a maiden Grand Slam title by sweeping aside third seeds Marcel Granollers and Horacio Zeballos 7-6(4) 6-4.
Urged on by a vocal crowd on Rod Laver Arena, the local duo never looked at risk of conceding to scoreboard pressure, despite serving from behind throughout the opening set.
Kyrgios and Kokkinakis stormed to a 5-2 lead in the tiebreak, and closed it out 7-4 as Kyrgios delivered massive serve out wide which Zeballos returned long.
The Aussie pairing created four break-point opportunities in the opening game of the second set and converted the fourth when Kokkinakis produced a sublime backhand cross-court winner which Zeballos left, presumably assuming it would be long.
At 2-4, the seeded pair, who hail from Spain and Argentina, respectively, held three break chances of their own and Granollers fired a backhand winner to level the set back on serve.
But serving to stay in the match at 4-5, the second seeds faced two match points. Without hesitation, Kokkinakis, 25, placed a perfect forehand lob to clinch victory as the Rod Laver Crowd erupted in cheers.
"I've played a lot of singles matches around the globe with amazing atmospheres but this week, with Thanasi and playing in front of you, nothing beats this," Kyrgios said.
"Playing in front of you guys brings the best out of us. I don't know if we'd have this result anywhere else," Kokkinakis added.
In addition to the third seeds, the entertaining partners have this fortnight taken out top seeds Nikola Mektic and Mate Pavic, sixth seeds Tim Puetz and Michael Venus, 15th seeds Ariel Behar and Gonzalo Escobar.
In the final, Kyrgios and Kokkinakis will take on fellow Australians Matt Ebden and Max Purcell, who upset AO 2021 finalists and second seeds Rajeev Ram and Joe Salisbury 6-3 7-6(9) – saving four set points in the second.
Ebden and Purcell, in only their second tournament together, also accounted for 10th seeds Wesley Koolhof and Neal Skupski and 13th seeds Raven Klaasen and Ben Mclachlan.
Known for their doubles prowess, the duo – also chasing a maiden Grand Slam men's doubles title – said they wanted Kyrgios and Kokkinakis to win so they could face off in the final.
"We know exactly what they can do, we respect how they can play. We have to find out [a] way to counter that, do what we do," Ebden said. "We're obviously going to go for it, we want to win as many slams as we can.
"There's a good chance starting Saturday night – these are the big matches you play for."
"Those two are great doubles players, we're not going to take 'em lightly, they're obviously playing some good tennis," said Kyrgios.
"They obviously play a lot more doubles than we do," acknowledged Kokkinakis. "It's going to be a really tough match but I think we know what we're capable of when we play together, playing with good energy.
"I think if we play how we've been playing, play with that energy, hopefully feed off the crowd again, play relaxed and free, we can do well."
In women's doubles, top seeds Barbora Krejcikova and Katerina Siniakova swept past third seeds Veronika Kudermetova and Elise Mertens 6-2 6-3 for the chance to play for a fourth Grand Slam title together.
The Czech duo struck 18 winners, double the nine of their opponents', and exacted revenge on Mertens – the Belgian who teamed up with Aryna Sabalenka to hand them a straight sets defeat in the women's doubles final last year.
MORE: Women's doubles results AO 22
"It feels amazing," Krejcikova said. "I think I can say both of us we are both proud, and looking forward [to] the finals."
"I'm just really excited and I hope I do much better than I did last year," Siniakova said, laughing.
On Sunday, the Czech favourites meet surprise finalists Anna Danilina and Beatriz Haddad Maia, following their upset of Japanese second seeds Shuko Aoyama and Ena Shibahara.
The Kazakhstani-Brazilian team, who won the Sydney International, took two hours and 19 minutes to secure the 6-4 5-7 6-4 victory.
"I'm really happy we got this result," Danilina said. "We're just trying to focus on every match here."